I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. ![]() Institutional Ethics Committee of B.J.Government Medical College and Sassoon General Hospitals, Pune 1, Maharashtra, India, gave ethical approval for this work, "Genomic Surveillance for SARS-CoV-2 in India: Indian SARS-CoV-2 Genomics Consortium (INSACOG)", vide Ref. The details of the IRB/oversight body that provided approval or exemption for the research described are given below: ![]() I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. This study did not receive any funding Author Declarations The authors have declared no competing interest. The study also shows that the clinical features and outcome of XBB.1.16* cases were similar to those of other co-circulating Omicron lineage infected cases in Maharashtra, India. The clinical features of COVID-19 cases infected with other co-circulating Omicron variants were similar to XBB.1.16* cases.Ĭonclusion The study reveals that XBB.1.16* lineage has become the most predominant SARS-CoV-2 lineage in India. Majority of XBB.1.16* cases who died belonged to an elderly age group (60 years and above), had underlying comorbid condition/s, and needed supplemental oxygen therapy. Out of 276 XBB.1.16* cases, seven (2.5%) cases succumbed to the disease. While 74.3% of XBB.1.16* cases were home-isolated 25.7% needed hospitalization/institutional quarantine, of these, 33.8% needed oxygen therapy. ![]() Among the XBB.1.16* cases, 91.7% were vaccinated with at least one dose of vaccine against COVID-19. Presence of comorbidity was found in 17.7% of the XBB.1.16* cases. The clinical features of COVID-19 cases with XBB.1.16* infection (XBB.1.16* cases, 276 in number) showed that 92% of those had a symptomatic disease, with fever (67%), cough (42%), rhinorrhoea (33.7%), body ache (14.5%) and fatigue (14.1%) being the most common symptoms. Of the 2,856 cases, 693 were from Maharashtra 386 of these were included in the clinical study. Results A total of 2,944 sequences were downloaded from the GISAID database, of which 2,856 were included in the study following data curation.
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